Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation

The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and l...

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Autori principali: Blanchet, Marie-Hélène, Le Good, J Ann, Mesnard, Daniel, Oorschot, Viola, Baflast, Stéphane, Minchiotti, Gabriella, Klumperman, Judith, Constam, Daniel B
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567404/
https://ncbi.nlm.nih.gov/pubmed/18772886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.174
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