Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

BACKGROUND: The laboratory rat (Rattus norvegicus) is one of the preferred model organisms in physiological and pharmacological research, although the availability of specific genetic models, especially gene knockouts, is limited. N-ethyl-N-nitrosourea (ENU)-driven target-selected mutagenesis is cur...

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Main Authors: van Boxtel, Ruben, Toonen, Pim W, Verheul, Mark, van Roekel, Henk S, Nijman, Isaac J, Guryev, Victor, Cuppen, Edwin
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567347/
https://ncbi.nlm.nih.gov/pubmed/18840264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-460
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