Efficient target-selected mutagenesis in Caenorhabditis elegans: Toward a knockout for every gene

Reverse genetic or gene-driven knockout approaches have contributed significantly to the success of model organisms for fundamental and biomedical research. Although various technologies are available for C. elegans, none of them scale very well for genome-wide application. To address this, we imple...

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Hauptverfasser: Cuppen, Edwin, Gort, Eelke, Hazendonk, Esther, Mudde, Josine, van de Belt, José, Nijman, Isaäc J., Guryev, Victor, Plasterk, Ronald H.A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2007
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Methods
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855173/
https://ncbi.nlm.nih.gov/pubmed/17416746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.6080607
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