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Systematic generation of in vivo G protein-coupled receptor mutants in the rat

G-protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors that are involved in a wide range of physiological and pathological processes, and are targets for many therapeutic interventions. However, genetic models in the rat, one of the most widely used model organisms i...

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Autors principals: van Boxtel, R, Vroling, B, Toonen, P, Nijman, I J, van Roekel, H, Verheul, M, Baakman, C, Guryev, V, Vriend, G, Cuppen, E
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3194067/
https://ncbi.nlm.nih.gov/pubmed/20531371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2010.44
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