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Cortical Development in the Presenilin-1 Null Mutant Mouse Fails After Splitting of the Preplate and is Not Due to a Failure of Reelin-Dependent Signaling
Cortical development is disrupted in presenilin-1 null mutant (Psen1−/−) mice. Prior studies have commented on similarities between Psen1−/− and reeler mice. Reelin induces phosphorylation of Dab1 and activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Psen1 is known to modulate PI3K/Akt...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566957/ https://ncbi.nlm.nih.gov/pubmed/18729224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21661 |
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