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Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
Short interfering RNAs (siRNAs) are valuable reagents for sequence-specific inhibition of gene expression via the RNA interference (RNAi) pathway. Although it has been proposed that the relative thermodynamic stability at the 5′-ends of siRNAs plays a crucial role in siRNA strand selection, we demon...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566866/ https://ncbi.nlm.nih.gov/pubmed/18782830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn584 |
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