Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology

BACKGROUND: Since prion gene-knockout mice do not contract prion diseases and animals in which production of prion protein (PrP) is reduced by half are resistant to the disease, we hypothesized that bovine animals with reduced PrP would be tolerant to BSE. Hence, attempts were made to produce bovine...

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Main Authors: Sutou, Shizuyo, Kunishi, Miho, Kudo, Toshiyuki, Wongsrikeao, Pimprapar, Miyagishi, Makoto, Otoi, Takeshige
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2007
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976095/
https://ncbi.nlm.nih.gov/pubmed/17655742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-7-44
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