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Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology

BACKGROUND: Since prion gene-knockout mice do not contract prion diseases and animals in which production of prion protein (PrP) is reduced by half are resistant to the disease, we hypothesized that bovine animals with reduced PrP would be tolerant to BSE. Hence, attempts were made to produce bovine...

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Detalhes bibliográficos
Main Authors: Sutou, Shizuyo, Kunishi, Miho, Kudo, Toshiyuki, Wongsrikeao, Pimprapar, Miyagishi, Makoto, Otoi, Takeshige
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976095/
https://ncbi.nlm.nih.gov/pubmed/17655742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-7-44
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