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Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria

The antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) is predominantly localized in the cytosol, but it is also found in mitochondria. Studies in yeast suggest that apoSOD1 is imported into mitochondria and trapped inside by folding and maturation, which is facilitated by its copper chaperone for...

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Main Authors: Kawamata, Hibiki, Manfredi, Giovanni
格式: Artigo
語言:Inglês
出版: Oxford University Press 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566526/
https://ncbi.nlm.nih.gov/pubmed/18703498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn226
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