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Different regulation of wild-type and mutant Cu,Zn superoxide dismutase localization in mammalian mitochondria
The antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) is predominantly localized in the cytosol, but it is also found in mitochondria. Studies in yeast suggest that apoSOD1 is imported into mitochondria and trapped inside by folding and maturation, which is facilitated by its copper chaperone for...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566526/ https://ncbi.nlm.nih.gov/pubmed/18703498 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn226 |
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