Detecting SNPs using a Synthetic Nanopore

We have discovered a voltage threshold for permeation through a synthetic nanopore of dsDNA bound to a restriction enzyme that depends on the sequence. Molecular Dynamic simulations reveal that the threshold is associated with a nanoNewton force required to rupture the DNA-protein complex. A single...

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Bibliographic Details
Main Authors: Zhao, Q., Sigalov, G., Dimitrov, V., Dorvel, B., Mirsaidov, U., Sligar, S., Aksimentiev, A., Timp, G.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565804/
https://ncbi.nlm.nih.gov/pubmed/17500578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl070668c
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