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Detecting SNPs using a Synthetic Nanopore
We have discovered a voltage threshold for permeation through a synthetic nanopore of dsDNA bound to a restriction enzyme that depends on the sequence. Molecular Dynamic simulations reveal that the threshold is associated with a nanoNewton force required to rupture the DNA-protein complex. A single...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2565804/ https://ncbi.nlm.nih.gov/pubmed/17500578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nl070668c |
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