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Biochemical Mechanisms Leading to Tryptophan 2,3-Dioxygenase Activation
Tryptophan 2,3-dioxygenase (TDO) is the first enzyme in the tryptophan oxidation pathway. It is a hemoprotein and its heme prosthetic group is present as a heme-ferric (heme-Fe(3+)) form that is not active. To be able to oxidize tryptophan, the heme-Fe(3+) form of the enzyme must be reduced to a hem...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2565576/ https://ncbi.nlm.nih.gov/pubmed/17212352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/arch.20159 |
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