Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

Maintaining stable tryptophan levels is required to control neuronal and immune activity. We report that tryptophan homeostasis is largely controlled by the stability of tryptophan 2,3-dioxygenase (TDO), the hepatic enzyme responsible for tryptophan catabolism. High tryptophan levels stabilize the a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Klaessens, Simon, Stroobant, Vincent, Hoffmann, Delia, Gyrd-Hansen, Mads, Pilotte, Luc, Vigneron, Nathalie, De Plaen, Etienne, Van den Eynde, Benoit J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201853/
https://ncbi.nlm.nih.gov/pubmed/34074763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022447118
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