Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO1) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance, and IDO1 inhibition is an active area of drug development. Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that als...

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Hlavní autoři: Pilotte, Luc, Larrieu, Pierre, Stroobant, Vincent, Colau, Didier, Dolušić, Eduard, Frédérick, Raphaël, De Plaen, Etienne, Uyttenhove, Catherine, Wouters, Johan, Masereel, Bernard, Van den Eynde, Benoît J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289319/
https://ncbi.nlm.nih.gov/pubmed/22308364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113873109
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