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Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO1) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance, and IDO1 inhibition is an active area of drug development. Tryptophan 2,3-dioxygenase (TDO) is an unrelated hepatic enzyme that als...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3289319/ https://ncbi.nlm.nih.gov/pubmed/22308364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113873109 |
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