BACE1, a Major Determinant of Selective Vulnerability of the Brain to Amyloid-β Amyloidogenesis, is Essential for Cognitive, Emotional, and Synaptic Functions

A transmembrane aspartyl protease termed β-site APP cleavage enzyme 1 (BACE1) that cleaves the amyloid-β precursor protein (APP), which is abundant in neurons, is required for the generation of amyloid-β (Aβ) peptides implicated in the pathogenesis of Alzheimer's disease (AD). We now demonstrat...

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Main Authors: Laird, Fiona M., Cai, Huaibin, Savonenko, Alena V., Farah, Mohamed H., He, Kaiwen, Melnikova, Tatyana, Wen, Hongjin, Chiang, Hsueh-Cheng, Xu, Guilian, Koliatsos, Vassilis E., Borchelt, David R., Price, Donald L., Lee, Hey-Kyoung, Wong, Philip C.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2005
Teme:
Neurobiology of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564291/
https://ncbi.nlm.nih.gov/pubmed/16354928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2766-05.2005
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