Loss of ALS2 Function Is Insufficient to Trigger Motor Neuron Degeneration in Knock-Out Mice But Predisposes Neurons to Oxidative Stress

Amyotrophic lateral sclerosis (ALS), the most common motor neuron disease, is caused by a selective loss of motor neurons in the CNS. Mutations in the ALS2 gene have been linked to one form of autosomal recessive juvenile onset ALS (ALS2). To investigate the pathogenic mechanisms of ALS2, we generat...

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Main Authors: Cai, Huaibin, Lin, Xian, Xie, Chengsong, Laird, Fiona M., Lai, Chen, Wen, Hongjin, Chiang, Hsueh-Cheng, Shim, Hoon, Farah, Mohamed H., Hoke, Ahmet, Price, Donald L., Wong, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2364727/
https://ncbi.nlm.nih.gov/pubmed/16107644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1645-05.2005
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