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Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism
Spinal muscular atrophy is a devastating disease that is characterized by degeneration and death of a specific subclass of motor neurons in the anterior horn of the spinal cord. Although the gene responsible, survival motor neuron 1 (SMN1), was identified 20 years ago, it has proven difficult to inv...
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| Udgivet i: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5181630/ https://ncbi.nlm.nih.gov/pubmed/27260405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw119 |
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