Mossy Fiber Long-Term Potentiation Deficits in BACE1 Knock-Outs Can Be Rescued by Activation of α7 Nicotinic Acetylcholine Receptors

β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1)—the neuronal β-secretase responsible for producing β-amyloid (Aβ) peptides—emerged as one of the key therapeutic targets of Alzheimer's disease (AD). Although complete ablation of the BACE1 gene prevents Aβ formation, we reported that B...

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Detalhes bibliográficos
Main Authors: Wang, Hui, Song, Lihua, Lee, Angela, Laird, Fiona, Wong, Philip C., Lee, Hey-Kyoung
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137882/
https://ncbi.nlm.nih.gov/pubmed/20943921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1070-10.2010
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