Mossy Fiber Long-Term Potentiation Deficits in BACE1 Knock-Outs Can Be Rescued by Activation of α7 Nicotinic Acetylcholine Receptors

β-Site amyloid precursor protein-cleaving enzyme 1 (BACE1)—the neuronal β-secretase responsible for producing β-amyloid (Aβ) peptides—emerged as one of the key therapeutic targets of Alzheimer's disease (AD). Although complete ablation of the BACE1 gene prevents Aβ formation, we reported that B...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Wang, Hui, Song, Lihua, Lee, Angela, Laird, Fiona, Wong, Philip C., Lee, Hey-Kyoung
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for Neuroscience 2010
Aiheet:
Brief Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137882/
https://ncbi.nlm.nih.gov/pubmed/20943921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1070-10.2010
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