Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: Effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea

Cytochrome P450 2D6 (CYP2D6), an important CYP isoform with regard to drug-drug interactions, accounts for the metabolism of ∼30% of all medications. To date, few studies have assessed the effects of botanical supplementation on human CYP2D6 activity in vivo. Six botanical extracts were evaluated in...

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Detalhes bibliográficos
Main Authors: Gurley, Bill J., Swain, Ashley, Hubbard, Martha A., Williams, D. Keith, Barone, Gary, Hartsfield, Faith, Tong, Yudong, Carrier, Danielle J., Cheboyina, Shreekar, Battu, Sunil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562884/
https://ncbi.nlm.nih.gov/pubmed/18214849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.200600300
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