Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans

Phytochemical-mediated modulation of p-glycoprotein (P-gp) and other drug transporters may underlie many herb-drug interactions. Serial plasma concentration-time profiles of the P-gp substrate, digoxin, were used to determine whether supplementation with milk thistle or black cohosh modified P-gp ac...

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Detalhes bibliográficos
Main Authors: Gurley, Bill J., Barone, Gary W., Williams, D. Keith, Carrier, Julie, Breen, Phillip, Yates, C. Ryan, Song, Peng-fei, Hubbard, Martha A., Tong, Yudong, Cheboyina, Sreekhar
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865121/
https://ncbi.nlm.nih.gov/pubmed/16221754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.105.006312
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