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PAR-1 activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand

We recently demonstrated that the occupancy of endothelial protein C receptor (EPCR) by its natural ligand activated protein C (APC)/protein C switches the protease activated receptor 1 (PAR-1)-dependent signaling specificity of thrombin from a disruptive to a protective effect in cultured human umb...

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Main Authors: Bae, Jong-Sup, Rezaie, Alireza R.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562749/
https://ncbi.nlm.nih.gov/pubmed/18612544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH08-02-0127
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