Optimization and Functional Effects of Stable Short Hairpin RNA Expression in Primary Human Lymphocytes via Lentiviral Vectors

Specific, potent, and sustained short hairpin RNA (shRNA)-mediated gene silencing is crucial for the successful application of RNA interference technology to therapeutic interventions. We examined the effects of shRNA expression in primary human lymphocytes (PBLs) using lentiviral vectors bearing di...

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Main Authors: An, Dong Sung, Qin, F. Xiao-Feng, Auyeung, Vincent C., Mao, Si Hua, Kung, Sam K. P., Baltimore, David, Chen, Irvin S. Y.
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562632/
https://ncbi.nlm.nih.gov/pubmed/16844419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2006.05.015
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