Lentiviral Delivery of a Vesicular Glutamate Transporter 1 (VGLUT1)-Targeting Short Hairpin RNA Vector Into the Mouse Hippocampus Impairs Cognition

Glutamate is the principle excitatory neurotransmitter in the mammalian brain, and dysregulation of glutamatergic neurotransmission is implicated in the pathophysiology of several psychiatric and neurological diseases. This study utilized novel lentiviral short hairpin RNA (shRNA) vectors to target...

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Autores principales: King, Madeleine V, Kurian, Nisha, Qin, Si, Papadopoulou, Nektaria, Westerink, Ben HC, Cremers, Thomas I, Epping-Jordan, Mark P, Le Poul, Emmanuel, Ray, David E, Fone, Kevin CF, Kendall, David A, Marsden, Charles A, Sharp, Tyson V
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870793/
https://ncbi.nlm.nih.gov/pubmed/24037344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.220
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