An Obligatory Heterodimer of 14-3-3β and 14-3-3ε Is Required for Aldosterone Regulation of the Epithelial Sodium Channel

Increased distal nephron sodium absorption in response to aldosterone involves Nedd4-2 phosphorylation, which blocks its ability to ubiquitylate ENaC and increases apical membrane channel density by reducing its endocytosis. Our prior work (Liang, X., Peters, K. W., Butterworth, M. B., and Frizzell,...

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Bibliographic Details
Main Authors: Liang, Xiubin, Butterworth, Michael B., Peters, Kathryn W., Walker, William H., Frizzell, Raymond A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562081/
https://ncbi.nlm.nih.gov/pubmed/18687683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803687200
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