Pif1 Helicase Directs Eukaryotic Okazaki Fragments toward the Two-nuclease Cleavage Pathway for Primer Removal

Eukaryotic Okazaki fragment maturation requires complete removal of the initiating RNA primer before ligation occurs. Polymerase δ (Pol δ) extends the upstream Okazaki fragment and displaces the 5′-end of the downstream primer into a single nucleotide flap, which is removed by FEN1 nuclease cleavage...

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Bibliografiske detaljer
Main Authors: Rossi, Marie L., Pike, Jason E., Wang, Wensheng, Burgers, Peter M. J., Campbell, Judith L., Bambara, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562071/
https://ncbi.nlm.nih.gov/pubmed/18689797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804550200
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