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Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing in Saccharomyces cerevisiae

Eukaryotic Okazaki fragments are initiated by a RNA/DNA primer, which is removed before the fragments are joined. Polymerase δ displaces the primer into a flap for processing. Dna2 nuclease/helicase and flap endonuclease 1 (FEN1) are proposed to cleave the flap. The single-stranded DNA-binding prote...

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Detalles Bibliográficos
Main Authors: Stewart, Jason A., Miller, Adam S., Campbell, Judith L., Bambara, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581594/
https://ncbi.nlm.nih.gov/pubmed/18799459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805965200
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