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Intracellular Sodium Regulates Proteolytic Activation of the Epithelial Sodium Channel

Na(+) transport across epithelia is mediated in part by the epithelial Na(+) channel ENaC. Previous work indicates that Na(+) is an important regulator of ENaC, providing a negative feedback mechanism to maintain Na(+) homeostasis. ENaC is synthesized as an inactive precursor, which is activated by...

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Autors principals: Knight, Kristin K., Wentzlaff, Danielle M., Snyder, Peter M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562069/
https://ncbi.nlm.nih.gov/pubmed/18662987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804176200
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