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Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

Genetic-dissection studies carried out with Down syndrome (DS) murine models point to the critical contribution of Dyrk1A overexpression to the motor abnormalities and cognitive deficits displayed in DS individuals. In the present study we have used a murine model overexpressing Dyrk1A (TgDyrk1A mic...

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書誌詳細
主要な著者: Ortiz-Abalia, Jon, Sahún, Ignasi, Altafaj, Xavier, Andreu, Núria, Estivill, Xavier, Dierssen, Mara, Fillat, Cristina
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561933/
https://ncbi.nlm.nih.gov/pubmed/18940310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.09.010
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