Flexibility versus “rigidity” of the functional architecture of AChE active center

Functional architecture of the AChE active center appears to be characterized by both structural “rigidity”, necessary to stabilize the catalytic triad as well as by flexibility in accommodating the different, high affinity AChE ligands. These seemingly conflicting structural properties of the activ...

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Bibliographic Details
Main Authors: Shafferman, Avigdor, Barak, Dov, Stein, Dana, Kronman, Chanoch, Velan, Baruch, Greig, Nigel H., Ordentlich, Arie
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561910/
https://ncbi.nlm.nih.gov/pubmed/18471807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2008.03.013
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