Flexibility versus “rigidity” of the functional architecture of AChE active center

Functional architecture of the AChE active center appears to be characterized by both structural “rigidity”, necessary to stabilize the catalytic triad as well as by flexibility in accommodating the different, high affinity AChE ligands. These seemingly conflicting structural properties of the activ...

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Main Authors: Shafferman, Avigdor, Barak, Dov, Stein, Dana, Kronman, Chanoch, Velan, Baruch, Greig, Nigel H., Ordentlich, Arie
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561910/
https://ncbi.nlm.nih.gov/pubmed/18471807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2008.03.013
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