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The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase

The usage by enzymes of specific binding pathways for gaseous substrates or products is debated. The crystal structure of the redox enzyme cholesterol oxidase, solved at sub-Ångstrom resolution, revealed a hydrophobic tunnel that may serve as a binding pathway for oxygen and hydrogen peroxide. This...

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Autors principals: Chen, Lin, Lyubimov, Artem Y., Brammer, Leighanne, Vrielink, Alice, Sampson, Nicole S.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561232/
https://ncbi.nlm.nih.gov/pubmed/18410129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800228w
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