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Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase
Two high-resolution structures of a double mutant of bacterial cholesterol oxidase in the presence or absence of a ligand, glycerol, are presented, showing the trajectory of glycerol as it binds in a Michaelis complex-like position in the active site. A group of three aromatic residues forces the ox...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2222809/ https://ncbi.nlm.nih.gov/pubmed/18029419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073168207 |
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