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The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261
The enzyme thymidylate synthase (TS) catalyzes the reductive methylation of 2′-deoxyuridine 5′-monophosphate (dUMP) to 2′-deoxythymidine 5′-monophosphate. Using kinetic and x-ray crystallography experiments, we have examined the role of the highly conserved Tyr-261 in the catalytic mechanism of TS....
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556892/ https://ncbi.nlm.nih.gov/pubmed/16768437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060152s |
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