The role of protein dynamics in thymidylate synthase catalysis: Variants of conserved dUMP-binding Tyr-261

The enzyme thymidylate synthase (TS) catalyzes the reductive methylation of 2′-deoxyuridine 5′-monophosphate (dUMP) to 2′-deoxythymidine 5′-monophosphate. Using kinetic and x-ray crystallography experiments, we have examined the role of the highly conserved Tyr-261 in the catalytic mechanism of TS....

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Bibliografiset tiedot
Päätekijät: Newby, Zachary, Lee, Tom T., Morse, Richard J., Liu, Lu, Liu, Yaoquan, Venkatraman, Prasanna, Santi, Daniel V., Finer-Moore, Janet S., Stroud, Robert M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556892/
https://ncbi.nlm.nih.gov/pubmed/16768437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060152s
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