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Iron Regulatory Proteins Increase Neuronal Vulnerability to Hydrogen Peroxide
Iron regulatory protein (IRP)-1 and IRP2 inhibit ferritin synthesis by binding to an iron responsive element in the 5' untranslated region of its mRNA. The present study tested the hypothesis that neurons lacking these proteins would be resistant to hydrogen peroxide (H(2)O(2)) toxicity. Wild-t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556571/ https://ncbi.nlm.nih.gov/pubmed/18655771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.07.061 |
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