Force-Clamp Spectroscopy Detects Residue Co-evolution in Enzyme Catalysis

Understanding how the catalytic mechanisms of enzymes are optimized through evolution remains a major challenge in molecular biology. The concept of co-evolution implicates that compensatory mutations occur to preserve the structure and function of proteins. We have combined statistical analysis of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Perez-Jimenez, Raul, Wiita, Arun P., Rodriguez-Larrea, David, Kosuri, Pallav, Gavira, Jose A., Sanchez-Ruiz, Jose M., Fernandez, Julio M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2555999/
https://ncbi.nlm.nih.gov/pubmed/18687682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803746200
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge