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The sarcin–ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit
The sarcin–ricin loop (SRL) of 23S rRNA in the large ribosomal subunit is a factor-binding site that is essential for GTP-catalyzed steps in translation, but its precise functional role is thus far unknown. Here, we replaced the 15-nucleotide SRL with a GAAA tetraloop and affinity purified the mutan...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553751/ https://ncbi.nlm.nih.gov/pubmed/18755834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1202108 |
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