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Interleukin-2–Independent Proliferation of Human Melanoma-Reactive T Lymphocytes Transduced With an Exogenous IL-2 Gene Is Stimulation Dependent

A major obstacle limiting the efficacy of adoptive T-cell transfer (adoptive immunotherapy) to treat patients with cancer is the short survival of the transferred cells. These in vitro activated T cells depend on the growth factor, interleukin (IL)-2, and may undergo apoptosis in vivo when they are...

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Bibliografische gegevens
Hoofdauteurs: Liu, Ke, Rosenberg, Steven A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2003
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553215/
https://ncbi.nlm.nih.gov/pubmed/12806273
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