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Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation.

The proliferative response of murine lymphocytes to interleukin-2 (IL-2) was examined under physico-chemical conditions present in solid tumours, namely low oxygen and glucose concentrations and acidic pH. Lymphocytes were cultured for four days in 30 U ml-1 IL-2 to simulate serum IL-2 concentration...

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Bibliografiske detaljer
Main Authors: Loeffler, D. A., Juneau, P. L., Masserant, S.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1992
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977437/
https://ncbi.nlm.nih.gov/pubmed/1419598
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