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Individually monitoring ligand-induced changes in the structure of the GABA(A) receptor at benzodiazepine binding site and non-binding site interfaces
The mechanisms by which the GABA and benzodiazepine (BZD) binding sites of the GABA-A receptor are allosterically coupled remain elusive. Here, we separately monitored ligand-induced structural changes in the BZD binding site (α/γ interface) and at aligned positions in the α/β interface. α(1)H101 an...
Tallennettuna:
| Päätekijät: | , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2552402/ https://ncbi.nlm.nih.gov/pubmed/18424553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.044891 |
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