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Prostaglandin E(2) Inhibits Specific Lung Fibroblast Functions via Selective Actions of PKA and Epac-1

Via their capacities for proliferation and synthesis of matrix proteins such as collagen, fibroblasts are key effectors in the pathogenesis of fibrotic disorders such as idiopathic pulmonary fibrosis. Prostaglandin E(2) (PGE(2)) potently inhibits these functions in lung fibroblasts through receptor...

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Detalhes bibliográficos
Main Authors: Huang, Steven K., Wettlaufer, Scott H., Chung, Jooho, Peters-Golden, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551707/
https://ncbi.nlm.nih.gov/pubmed/18421013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0080OC
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