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Taxol Allosterically Alters the Dynamics of the Tubulin Dimer and Increases the Flexibility of Microtubules

Taxol is a commonly used antitumor agent that hyperstabilizes microtubules and prevents cell division. The interaction of Taxol with tubulin and the microtubule has been studied through a wide array of experimental techniques; however, the exact molecular mechanism by which Taxol stabilizes microtub...

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מידע ביבליוגרפי
Main Authors: Mitra, Arpita, Sept, David
פורמט: Artigo
שפה:Inglês
יצא לאור: The Biophysical Society 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2547448/
https://ncbi.nlm.nih.gov/pubmed/18621813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.133884
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