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A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response

Tel1/ATM, a conserved phosphatidylinositol 3-kinase-related kinase (PIKK), acts in the response to DNA damage and regulates telomere maintenance. PIKK family members share an extended N-terminal region of low sequence homology. Sequence alignment of the N terminus of Tel1/ATM orthologs revealed a co...

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Detalhes bibliográficos
Main Authors: Seidel, Jeffrey J., Anderson, Carol M., Blackburn, Elizabeth H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546937/
https://ncbi.nlm.nih.gov/pubmed/18625723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00326-08
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