Multifunctional Role of ATM/Tel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance

The mammalian protein kinase ataxia telangiectasia mutated (ATM) is a key regulator of the DNA double-strand-break response and belongs to the evolutionary conserved phosphatidylinositol-3-kinase-related protein kinases. ATM deficiency causes ataxia telangiectasia (AT), a genetic disorder that is ch...

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Autores principales: Di Domenico, Enea Gino, Romano, Elena, Del Porto, Paola, Ascenzioni, Fiorentina
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163350/
https://ncbi.nlm.nih.gov/pubmed/25247188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/787404
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