Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection

During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely characterized. In a cohort of 98 individuals newly infected with HIV-1 subtype B, we longitudinally ch...

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Autores principales: Brumme, Zabrina L., Brumme, Chanson J., Carlson, Jonathan, Streeck, Hendrik, John, Mina, Eichbaum, Quentin, Block, Brian L., Baker, Brett, Kadie, Carl, Markowitz, Martin, Jessen, Heiko, Kelleher, Anthony D., Rosenberg, Eric, Kaldor, John, Yuki, Yuko, Carrington, Mary, Allen, Todd M., Mallal, Simon, Altfeld, Marcus, Heckerman, David, Walker, Bruce D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546878/
https://ncbi.nlm.nih.gov/pubmed/18614631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01041-08
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