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Use of mchI Encoding Immunity to the Antimicrobial Peptide Microcin H47 as a Plasmid Selection Marker in Attenuated Bacterial Live Vectors

Live attenuated bacterial strains expressing heterologous antigens represent an attractive vaccine development strategy. However, the use of drug resistance genes for the selection of expression plasmids introduced into live vectors poses theoretical health risks. Therefore, we developed a novel app...

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Bibliographic Details
Main Authors: Fang, Chee-Mun, Wang, Jin Yuan, Chinchilla, Magaly, Levine, Myron M., Blackwelder, William C., Galen, James E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546845/
https://ncbi.nlm.nih.gov/pubmed/18663003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00487-08
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