A Nasal Interleukin-12 DNA Vaccine Coexpressing Yersinia pestis F1-V Fusion Protein Confers Protection against Pneumonic Plague

Previous studies have shown that mucosal application of interleukin-12 (IL-12) can stimulate elevated secretory immunoglobulin A (IgA) responses. Since possible exposure to plague is via Yersinia pestis-laden aerosols that results in pneumonic plague, arming both the mucosal and systemic immune syst...

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Detalhes bibliográficos
Main Authors: Yamanaka, Hitoki, Hoyt, Teri, Yang, Xinghong, Golden, Sarah, Bosio, Catharine M., Crist, Kathryn, Becker, Todd, Maddaloni, Massimo, Pascual, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546814/
https://ncbi.nlm.nih.gov/pubmed/18694965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00581-08
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