D27-pLpxL, an Avirulent Strain of Yersinia pestis, Primes T Cells That Protect against Pneumonic Plague

Vaccinating with live, conditionally attenuated, pigmentation (Pgm)-deficient Yersinia pestis primes T cells that protect mice against pneumonic plague. However, Pgm-deficient strains are not considered safe for human use because they retain substantial virulence in animal models. Y. pestis strains...

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Detalhes bibliográficos
Main Authors: Szaba, Frank M., Kummer, Lawrence W., Wilhelm, Lindsey B., Lin, Jr-Shiuan, Parent, Michelle A., Montminy-Paquette, Sara W., Lien, Egil, Johnson, Lawrence L., Smiley, Stephen T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747924/
https://ncbi.nlm.nih.gov/pubmed/19620344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00273-09
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